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Valgerdur Tomasdottir has recently defended her PhD thesis entitled „The effects of dietary fish oil on the induction and resolution of antigen-induced inflammation“.
Dietary n-3 polyunsaturated fatty acids influence the inductive phase of inflammation but less is known about their effects on resolution of inflammation or on the adaptive immune response.
The study examined the effects of dietary fish oil on induction, resolution and the adaptive immune response in antigen-induced inflammation in mice.
The results of the study show that in the acute phase, dietary fish oil reduced the number of peritoneal neutrophils, decreased the resolution interval and lowered the levels of pro-inflammatory cytokines (IL-6 and G-CSF) and chemokines (CXCL1 and CCL11) in the peritoneal fluid. In the resolution phase, dietary fish oil increased the expression of D6 and CCR7 on peritoneal macrophages and the concentrations of the anti-inflammatory mediators TGF-β and sIL-6R in the peritonal fluid. In the late resolution phase, dietary fish oil increased the number of peritoneal eosinophils and CD138+ macrophages. In addition, dietary fish oil increased the number of peritoneal T and B1 cells and splenic IgM+ cells and increased serum levels of mBSA-specific IgM antibodies.
These results demonstrate a suppressive effect of dietary fish oil on the inductive phase of inflammation and indicate an enhancing effect on resolution of inflammation as well as on the B1 adaptive immune response.
Supervisors in the thesis were professor Ingibjorg Hardardottir (Biochemistry and Molecular Biology, Faculty of Medicine, Biomedical Center, University of Iceland) and professor Jona Freysdottir (Department of Immunology, Faculty of Medicine, Biomedical Center, University of Iceland and Centre for Rheumatology Research and Department of Immunology, Landspitali – The National University Hospital of Iceland).